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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRKDC All Species: 16.97
Human Site: S690 Identified Species: 41.48
UniProt: P78527 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P78527 NP_001075109.1 4128 469089 S690 F E G V S P K S L K H S P E D
Chimpanzee Pan troglodytes XP_001147162 4128 468882 S690 F E G V S P Q S L K H S P E D
Rhesus Macaque Macaca mulatta XP_001100610 4128 469402 K690 F E T L S Q K K K K N C P K K
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P97313 4128 471369 S689 F E G I S P K S L K H S P E D
Rat Rattus norvegicus NP_001101797 2098 241314
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514950 4153 474137 S710 F E G V S P R S L K K S P E D
Chicken Gallus gallus Q8QGX4 4134 472639 S686 F E G V G P K S L R K A T E D
Frog Xenopus laevis Q9DEI1 4146 473487 I711 F E G F T S K I Y K K A P E D
Zebra Danio Brachydanio rerio XP_001919588 4119 467204 P693 F Q D V K Q C P K Q V G G S T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_781813 1817 205237
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 97.5 N.A. N.A. 79.1 39.2 N.A. 74.1 68.8 64 58.5 N.A. N.A. N.A. N.A. 20.8
Protein Similarity: 100 99.8 98.8 N.A. N.A. 88.7 44.7 N.A. 85.4 82.5 79.8 76.1 N.A. N.A. N.A. N.A. 31.6
P-Site Identity: 100 93.3 40 N.A. N.A. 93.3 0 N.A. 86.6 66.6 53.3 13.3 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 100 60 N.A. N.A. 100 0 N.A. 93.3 80 66.6 26.6 N.A. N.A. N.A. N.A. 0
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 20 0 0 0 % A
% Cys: 0 0 0 0 0 0 10 0 0 0 0 10 0 0 0 % C
% Asp: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 60 % D
% Glu: 0 70 0 0 0 0 0 0 0 0 0 0 0 60 0 % E
% Phe: 80 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 60 0 10 0 0 0 0 0 0 10 10 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 30 0 0 0 0 % H
% Ile: 0 0 0 10 0 0 0 10 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 10 0 50 10 20 60 30 0 0 10 10 % K
% Leu: 0 0 0 10 0 0 0 0 50 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % N
% Pro: 0 0 0 0 0 50 0 10 0 0 0 0 60 0 0 % P
% Gln: 0 10 0 0 0 20 10 0 0 10 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 10 0 0 10 0 0 0 0 0 % R
% Ser: 0 0 0 0 50 10 0 50 0 0 0 40 0 10 0 % S
% Thr: 0 0 10 0 10 0 0 0 0 0 0 0 10 0 10 % T
% Val: 0 0 0 50 0 0 0 0 0 0 10 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _